La neurociencia dice que este simple hábito de sueño literalmente limpiará tu cerebro

La neurociencia dice que este simple hábito de sueño literalmente limpiará tu cerebro

Cuando reviso historias sobre neurociencia que pueden ayudar a los empresarios a entrenar sus cerebros para mejorar la salud y el rendimiento, a menudo hay un momento al final en el que los investigadores Cuidado con las limitaciones de su trabajo.

  • A veces es una advertencia que se deriva de una conclusión adicional que la gente podría estar inclinada a hacer.
  • A veces es un indicio melancólico o maravilloso de áreas en las que se debe investigar más.
  • A menudo es un recordatorio de no adelantarnos demasiado debido a nuestro viejo amigo, la correlación frente a la causalidad.

Pero de vez en cuando me encuentro con algo que ofrece información aún más útil cuando trabajamos hacia atrás, y lo inspira a leer investigaciones anteriores que muestran cómo la neurociencia sugiere que las personas pueden mejorar su salud.

Esto ha sucedido recientemente, y tiene que ver con los estudios sobre el buen sueño, su propósito biológico y, francamente, la falta de buen sueño que aún denuncian muchos empresarios y líderes empresariales.

Pasemos a la investigación que provocó esta exploración.

Escribiendo en la revista revisada por pares, Neurodegeneración traslacionalInvestigadores universitarios en Australia dijeron que querían estudiar enfermedades devastadoras de las neuronas motoras como la esclerosis lateral amiotrófica (ELA), también conocida como enfermedad de Lou Gehrig.

No existe una cura conocida para la ELA, y los investigadores querían determinar si el deterioro del sistema glinfático del cuerpo, que elimina los desechos del cerebro, podría estar relacionado con la aparición de la enfermedad desde el principio.

Para comprender su experimento, primero debemos comprender un poco cómo nuestros cuerpos procesan las proteínas y cómo funciona el sistema glinfático.

como los investigadores explicadonuestros cuerpos dependen de largas cadenas de proteínas, cada una compuesta por aminoácidos, que se organizan “para realizar tareas específicas, como producir anticuerpos para combatir infecciones, apoyar células o transportar moléculas”.

Cuando las cosas no funcionan correctamente, el cuerpo puede acumular “proteínas mal plegadas”. Es el sistema glinfático el que elimina este tipo de desechos del cerebro y funciona principalmente mientras dormimos.

El estudio de los investigadores involucró ratones que habían sido modificados genéticamente para expresar una proteína humana que se encuentra en pacientes humanos con ELA. Cuando alimentaron a los ratones con alimentos enriquecidos con un antibiótico que contrarrestaba la proteína humana, envejecieron normalmente.

Pero si alimentaron a los ratones con comida sin que Dados los antibióticos y las proteínas humanas modificadas acumuladas, los ratones mostraron “signos clásicos de ELA, que incluyen deterioro muscular progresivo y atrofia cerebral”.

A partir de ahí, usaron una resonancia magnética para examinar las estructuras cerebrales de los ratones y encontraron que en los ratones con proteína humana desenmascarada, la eliminación glifática era significativamente menos efectiva que en los ratones que no habían sido modificados genéticamente.

Otras contribuciones a la limpieza glifática que los autores del estudio citan en base a investigaciones previas:

  • Comer ácidos grasos omega-3 que se encuentran en el pescado de mar;
  • consumo moderado de alcohol (énfasis en moderado; altas dosis de alcohol tenían el efecto contrario);
  • Ejercicio; y
  • dormir de tu lado

Es el último contribuyente adicional en saltar. Efectivamente, hay una gran cantidad de investigaciones sobre ratones, la limpieza glinfática y el sueño que sugieren que dormir de lado, en lugar de boca abajo o boca arriba, puede aumentar la función de limpieza cerebral de la limpieza glinfática.

“Las razones de esto aún no se han dilucidado por completo”, escribió El autor del estudio, David Wright, “pero puede estar refiriéndose a los efectos de la gravedad, la compresión y el estiramiento del tejido”.

Entonces, ¿dónde te deja todo esto? Por supuesto, espero que nunca luches personalmente con la enfermedad de las neuronas motoras. Pero también sigo escuchando de empresarios que están interesados ​​en trucos de vida simples y respaldados por la ciencia que pueden mejorar su productividad y su salud.

Aquí es donde parece que un simple hábito como aprender a dormir de lado podría ofrecer beneficios tangibles. Incluso podría ser más fácil de lo que piensas; Me he encontrado con varios estudios que sugieren que la mayoría de las personas automáticamente duermen de lado de todos modos.

Bueno, es posible que ya esté familiarizado con ese estudio anterior, pero en caso de que se esté suscribiendo al Revista de neurociencia caducado, vale la pena volver a visitarlo.

“[L]La posición para dormir ya es la posición favorita para los humanos y la mayoría de los animales”, escribió uno de los autores del estudio, y agregó que “una función biológica clara del sueño es ‘limpiar’ el desorden que se acumula mientras estamos despiertos. “

Al menos, como escribo en mi e-book gratuito Neurociencia: 13 formas de entender y entrenar tu cerebro para la vidaNo hay nada más fascinante que el cerebro humano y la forma inesperada en que funciona.

La salud del sueño siempre está en la parte superior de la lista. Y eso cuenta, no importa cómo llegue a las ideas.

Las opiniones expresadas aquí por los columnistas de Heaven32 son propias y no de Heaven32.

, university researchers in Australia explained that they set out to study devastating motor neuron diseases like amyotrophic lateral sclerosis (ALS), which is also known as Lou Gehrig's disease.  \n There's no known cure for ALS, and the researchers wanted to determine whether impairment of the body's glymphatic system, which removes waste from the brain, might be associated with onset of the disease to begin with.  \n In order to understand their experiment, we first have to understand a little bit about how our bodies process protein, and how the glymphatic system works.  \n As the researchers explained, our bodies rely on long chains of proteins, each made up of amino acids, which align \"to perform specific tasks like creating antibodies to fight off infection, supporting cells or transporting molecules.\" \n When things don't work correctly, the body can accumulate \"misfolded proteins.\" It's the glymphatic system that removes this kind of waste from the brain, working mostly while we sleep. \n So, the researchers' study involved mice that had been genetically modified to express a human protein that is seen in human patients with ALS. When they fed the mice food that had been laced with an antibiotic that counteracted the human protein, they aged normally.  \n But, when they fed the mice food without antibiotics, and the modified human proteins accumulated, the mice began to show \"classical signs of ALS including progressive muscle impairments and brain atrophy.\" \n From there, they used an MRI to look at the mice's brain structures, and they found that in the mice with the human protein unobscured, glymphatic clearance was significantly less effective than the mice who had not been genetically modified. \n Other contributors to glymphatic clearance, which the study authors cites based on previous research: \n
    \t
  • consumption of Omega-3 fatty acids, which are found in marine-based fish;
  • \t
  • moderate alcohol consumption (the emphasis is on \"moderate;\" high doses of alcohol had the opposite effect);
  • \t
  • exercise; and
  • \t
  • sleeping on your side.
\n It's that last extra contributor that leaped out. Sure enough, there's a whole body of research on mice, glymphatic clearance, and sleep that suggests that sleeping on one's side, rather than face-down or on your back, can increase the brain-cleaning function of glymphatic clearance. \n \"The reasons for this are not yet fully understood,\" wrote study author David Wright, \"but possibly relates to the effects of gravity, compression and stretching of tissue.\" \n So, where does all this leave you? Certainly, I hope you never have to contend personally with motor neuron diseases. But, I also hear constantly from entrepreneurs that they're interested in easy, science-backed life hacks that can improve their productivity and their health. \n Here, it seems that a simple habit like learning to sleep on your side might offer tangible benefits. It might be even easier than you might suspect; I came across several studies suggesting a majority of people sleep on their sides automatically, anyway. \n Now, maybe you're already familiar with this earlier study, but just in case your subscription to the Journal of Neuroscience has lapsed, it's worth revisiting. \n \"[L]ateral sleep position is already the most popular in human and most animals,\" one of the authors of that study wrote, adding that \"a distinct biological function of sleep and that is to 'clean up' the mess that accumulates while we are awake.\" \n Anyway, as I write in my free e-book Neuroscience: 13 Ways to Understand and Train Your Brain for Life, there's nothing more fascinating than the human brain, and the unexpected ways in which it works.  \n Sleep health is always at the top of the list. 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